Key facts
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What it is: A combination ED tablet that typically contains sildenafil (generic Viagra) + tadalafil (generic Cialis). Exact strengths vary by maker.
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How it works: Dual PDE-5 inhibition to enhance penile blood flow during sexual stimulation.
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Onset/Duration: Sildenafil acts in ~30–60 min for 4–6 h; tadalafil lasts up to ~36 h.
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Regulatory note: Combo products like “Super Sildalis” are not FDA-approved in the U.S.; availability and quality vary by country and manufacturer.
Is combining sildenafil and tadalafil a good idea?
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Evidence for superior efficacy of fixed combos vs single agents is limited.
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Combining PDE-5 inhibitors can increase side-effect risk (headache, flushing, dizziness, hypotension, priapism).
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Do not use dual therapy unless specifically prescribed and monitored by a licensed clinician.
How it works (mechanism)
Both drugs inhibit phosphodiesterase-5, preserving cGMP in penile smooth muscle. With arousal, this relaxes cavernosal tissue, increases inflow, and supports erection. Tadalafil’s longer half-life may extend the response window.
Dosing guidance (clinical caution)
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Follow your prescriber’s exact directions.
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Do not exceed one dose in 24 hours. Because tadalafil persists ~36 h, avoid stacking other PDE-5s within that period unless your clinician instructs otherwise.
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Take with water 30–60 minutes before sex. Avoid heavy/high-fat meals (they delay sildenafil). Limit alcohol to improve response and reduce dizziness.
Who should not use it
Avoid if you:
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Use nitrates (e.g., nitroglycerin) or riociguat
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Had recent MI/stroke, have unstable angina, severe hypotension/uncontrolled hypertension
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Have severe liver/kidney disease without supervision
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Have certain retinal disorders (e.g., retinitis pigmentosa) or prior NAION
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Are allergic to sildenafil/tadalafil or excipients
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Are women or under 18
Drug/food interactions
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Contraindicated: Nitrates, riociguat
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Caution/adjust: Alpha-blockers (tamsulosin), strong CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin), some antihypertensives, SSRIs/SNRIs, antihistamines
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Grapefruit can raise levels; avoid around dosing.
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High-fat meals delay onset.
Possible side effects
Common (usually mild, transient): Headache, flushing, nasal congestion, indigestion, dizziness; back/muscle aches (more with tadalafil), facial warmth, visual tint.
Serious—stop and seek urgent care: Chest pain, severe dizziness/syncope, priapism (erection >4 h), sudden vision/hearing loss, irregular heartbeat, allergic reaction.
Storage
Store at room temperature, protected from heat and light. Keep in original packaging. Keep out of reach of children and pets.
Smart use tips
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Give any ED plan 4–8 properly timed attempts before judging failure.
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Optimize basics: low alcohol, light meals, 15–20 min arousal, good sleep.
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If results vary, discuss single-agent titration (sildenafil 25–100 mg or tadalafil 5–20 mg / daily 2.5–5 mg) with a clinician before considering combinations.
Buying safely (USA)
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Use a licensed prescriber and state-licensed pharmacy.
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Verify lot, expiry, and tamper-evident packaging.
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Be cautious with unverified online sellers; counterfeit risk is high.
FAQ
Does Super Sildalis work without arousal? No—sexual stimulation is required.
Is it stronger than single drugs? Not conclusively. Side-effects may increase.
Can I take another ED pill on top? Not without explicit clinician guidance.
How long does it last? Expect a window influenced by tadalafil’s ~36 h half-life, but individual response varies.